Research for a better future
We highlight a few significant research advances over the past year
Faculty members in the College of Public Health and Health Professions are tackling some of the world’s greatest health challenges, from infectious diseases to chronic conditions, such as diabetes, substance use and obesity. Over the past year, faculty received more than $36 million in research funding and published a number of important scientific findings in major journals. Here, we highlight a few significant research studies and new projects.
Hidden diabetes risk factor
A third of adults over the age of 45 who don’t look like they could be at risk for developing diabetes — they’re slender — may actually meet the criteria for prediabetes. Based on the results of a recent study published in BMJ Open, authors Ara Jo, Ph.D., a clinical assistant professor of health services research, management and policy, and Arch Mainous, Ph.D., chair of the department, propose that body fat percentage is a better predictor of prediabetes and diabetes risk than body mass index.
Ashby Walker, Ph.D., an assistant professor of health services research, management and policy, and colleagues have received a $1.6 million grant from The Leona M. & Harry B. Helmsley Charitable Trust to study ways to improve access to care for underserved adults and children with Type 1 diabetes.
Getting back in the game
Taking immediate action to remove athletes with concussion from play could help them recover faster. That’s the conclusion of a new study by doctoral student Breton Asken, Russell Bauer, Ph.D., a professor of clinical and health psychology, and colleagues. In an analysis of 506 sports-related concussions among college athletes in 18 sports published in the American Journal of Sports Medicine, the team found that athletes who ceased activities after injury missed about three fewer days of competition than those who delayed reporting their injuries.
Stopping the spread of infectious diseases
The Democratic Republic of Congo employed a new Ebola vaccine to combat an outbreak of the virus this spring, thanks in part to the work of Ira Longini, Ph.D., a professor of biostatistics. Longini and World Health Organization colleagues designed the vaccine’s clinical trial in response to the 2014 outbreak using an innovative “ring vaccination” method. A paper in The Lancet on the team’s final findings, which found the vaccine to be 100 percent effective, was ranked No. 9 on Altmetric’s list of the top 100 scientific articles of 2017.
John Lednicky, Ph.D., a research professor of environmental and global health, and fellow researchers made a number of significant discoveries over the past year involving emerging mosquito-borne viruses. These include evidence of Zika transmission through breast milk, a new “American” strain of chikungunya in mosquitos in Haiti, and detection of Madariaga in a Venezuelan child.
Safe driving and community mobility
A lack of transportation can have a profoundly negative effect on a person’s health and well-being. Researchers led by Sherrilene Classen, Ph.D., M.P.H., OTR/L, chair of occupational therapy, are working to ensure that older adults and people of all ages who have health conditions that may affect their ability to drive can remain active and mobile in their communities. In a new study funded by the Department of Transportation and UF’s Transportation Institute, Classen and her team are evaluating older adults’ experiences with autonomous vehicle technology. With funding from AAA, the team is updating the consumer guide “Smart Features for Older Drivers” to include new in-vehicle and automated vehicle technologies. Other ongoing studies include a driving intervention to improve safe driving among combat veterans, a resource center to increase community mobility options for seniors and others who can no longer drive, and the development of a computer-based training program to reduce distracted driving in teens.
Keeping weight off
Scientists have long believed that following a significant weight loss, people are able to maintain the lower weight for a while. However, in a study published earlier this year in Obesity, Kathyrn Ross, Ph.D., an assistant professor of clinical and health psychology, reported that participants in a 12-week weight-loss program started regaining weight much sooner, right around the end of the program. She is working to develop interventions that address challenges of weight maintenance.
David Fedele, Ph.D., an assistant professor of clinical and health psychology, David Janicke, Ph.D., a professor in the department, and Robert Lucero, Ph.D., of the UF College of Nursing, recently received a grant to develop a mobile app that seeks to help children who have asthma achieve a healthier weight.
Improving health outcomes for people with HIV
While there is some evidence that marijuana may improve HIV-related symptoms, there is still a lot experts do not know about its health effects. Robert Cook, M.D., M.P.H., a professor of epidemiology and medicine, hopes to answer some of these questions with support from a new $3.2 million grant from the National Institute on Drug Abuse. It is believed to be the largest and most comprehensive study of its kind. Cook also co-leads a new NIH-funded training grant to mentor the next generation of scientists to address issues related to alcohol use among people with HIV.
Predicting pain
Knowing who is at risk for chronic pain could help clinicians tailor treatments to control pain and limit prescription drug use. In a study published in the journal Physical Therapy, Jason Beneciuk, Ph.D., D.P.T., M.P.H., a research assistant professor of physical therapy, and his team pinpointed patient characteristics associated with long-term musculoskeletal pain. Patients who had greater initial pain, a higher number of other health problems, additional symptoms from other body systems and more pain-related psychological distress were more likely to continue to have pain one year after physical therapy treatment.
Aging and the brain
Cognitive training programs have been shown to improve memory, reasoning and speed of processing in older adults. Now in a new study funded by a $5.7 million grant from the National Institute on Aging, researchers will examine whether the effects of cognitive training can be enhanced by pairing it with electrical stimulation delivered by a weak current through electrodes placed on the scalp. The study is led by clinical and health psychology faculty Adam Woods, Ph.D., Ronald Cohen, Ph.D., and Michael Marsiske, Ph.D. They and other neuropsychologists in the department, including Dawn Bowers, Ph.D., Catherine Price, Ph.D., and Glenn Smith, Ph.D., are studying various ways to combat the effects of aging and disease on the brain.
Breakthrough in Duchenne treatment
In the spring, researchers announced that a new drug called edasalonexent had been shown to slow the progression of Duchenne muscular dystrophy. The finding represents a significant advance in treatment for a disease that can lead to patients needing to use a wheelchair by their early teens. Krista Vandenborne, Ph.D., P.T., chair of physical therapy, played a major role in the study and in several other Duchenne clinical trials. Using MRI, Vandenborne has developed techniques to measure the earliest changes in muscle integrity, providing rapid feedback for Duchenne clinical trials and important information on the disease’s natural progression. Her methods have become the gold standard for measuring muscle changes in this disease.